I found a bunch of .45 GAP 200 grain Gold Dot at an LE supplier at a very good price. After doing some digging through safety and feasibility issues on the S&W Forum, I decided to try some of the GAP ammunition in my S&W 22-4 4". .45 GAP has a chamber pressure similar to .45 ACP (+p). I used the same moon clips that I use with ..45 ACP. The round chronographed with an average velocity of 966 fps; the slowest was 933 fps. The average is just 4 fps slower than advertised by Speer. The 200 grain Lawman practice load was actually achieved a faster average than the Gold Dot. The recoil was very similar to that of the 185 grain Remington Golden Saber std pressure in the same revolver. When fired the GAP through my "hillbilly" clothing barrier of overalls, sweat shirt and T-shirt into water filled milk jugs, I got an expansion of .75 caliber. So in a pinch, it'll do.
“If you will not fight for right when you can easily win without bloodshed; if you will not fight when your victory is sure and not too costly; you may come to the moment when you will have to fight with all the odds against you and only a precarious chance of survival. There may even be a worse case. You may have to fight when there is no hope of victory, because it is better to perish than to live as slaves.”